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J Clin Pathol. 2015 Mar;68(3):200-5. doi: 10.1136/jclinpath-2014-202735. Epub 2014 Dec 4.

CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.

Author information

1
Department of Urology, Singapore General Hospital, Singapore, Singapore.
2
Department of Pathology, Singapore General Hospital, Singapore, Singapore.
3
Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre, Singapore, Singapore Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore.
4
Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre, Singapore, Singapore Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Erratum in

Abstract

AIMS:

We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC.

METHODS:

Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ(2)/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan-Meier method and compared using Cox regression analysis.

RESULTS:

Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival.

CONCLUSIONS:

CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes.

KEYWORDS:

IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; UROPATHOLOGY

PMID:
25477528
PMCID:
PMC4345982
DOI:
10.1136/jclinpath-2014-202735
[Indexed for MEDLINE]
Free PMC Article

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