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Cell Death Dis. 2014 Dec 4;5:e1552. doi: 10.1038/cddis.2014.520.

Koschei the immortal and anti-aging drugs.

Author information

1
Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Elm and Carlton Streets, Buffalo, NY, USA.

Abstract

In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.

PMID:
25476900
PMCID:
PMC4649836
DOI:
10.1038/cddis.2014.520
[Indexed for MEDLINE]
Free PMC Article

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