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J Oral Microbiol. 2014 Dec 3;6:26189. doi: 10.3402/jom.v6.26189. eCollection 2014.

Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.

Author information

1
Division of Oral Microbiology and Immunology, Department of Operative and Preventive Dentistry & Periodontology, RWTH Aachen University Hospital, Aachen, Germany; gconrads@ukaachen.de.
2
Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
3
Institute of Bioprocess and Biosystems, Technical University Hamburg, Harburg, Germany.
4
Division of Oral Microbiology and Immunology, Department of Operative and Preventive Dentistry & Periodontology, RWTH Aachen University Hospital, Aachen, Germany.
5
Helmholtz-Centre for Infection Research, Group Microbial Communication, Division of Microbial Pathogenesis, Braunschweig, Germany.

Abstract

BACKGROUND:

Two closely related species of mutans streptococci, namely Streptococcus mutans and Streptococcus sobrinus, are associated with dental caries in humans. Their acidogenic and aciduric capacity is directly associated with the cariogenic potential of these bacteria. To survive acidic and temporarily harsh conditions in the human oral cavity with hundreds of other microbial co-colonizers as competitors, both species have developed numerous mechanisms for adaptation.

OBJECTIVES:

The recently published novel genome information for both species is used to elucidate genetic similarities but especially differences and to discuss the impact on cariogenicity of the corresponding phenotypic properties including adhesion, carbohydrate uptake and fermentation, acid tolerance, signaling by two component systems, competence, and oxidative stress resistance.

CONCLUSIONS:

S. sobrinus can down-regulate the SpaA-mediated adherence to the pellicle. It has a smaller number of two-component signaling systems and bacteriocin-related genes than S. mutans, but all or even more immunity proteins. It lacks the central competence genes comC, comS, and comR. There are more genes coding for glucosyltransferases and a novel energy production pathway formed by lactate oxidase, which is not found in S. mutans. Both species show considerable differences in the regulation of fructan catabolism. However, both S. mutans and S. sobrinus share most of these traits and should therefore be considered as equally virulent with regard to dental caries.

KEYWORDS:

Mutans streptococci; adhesion; bacteriocins; cariogenicity; comparative genomics; competence; sugar metabolism; two-component-systems

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