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Cell Res. 2015 Jan;25(1):3-4. doi: 10.1038/cr.2014.162. Epub 2014 Dec 5.

FTO: linking m6A demethylation to adipogenesis.

Author information

1
1] Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel [2] Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978 Israel.
2
Sheba Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel.

Abstract

Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

PMID:
25475057
PMCID:
PMC4650590
DOI:
10.1038/cr.2014.162
[Indexed for MEDLINE]
Free PMC Article
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