Send to

Choose Destination
PLoS One. 2014 Dec 4;9(12):e113996. doi: 10.1371/journal.pone.0113996. eCollection 2014.

Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two.

Collaborators (144)

Weiland SK, Büchele G, Dentler C, Jaensch A, Rzehak P, Weinmayr G, Priftanji A, Shkurti A, Simenati J, Grabocka E, Shyti K, Agolli S, Gurakuqi A, Stein RT, Urrutia de Pereira M, Jones MH, Pitrez PM, Cooper PJ, Chico M, Chen YZ, Lai CK, Wong GW, Riikjärv MA, Annus T, Annesi-Maesano I, Gotua M, Rukhadze M, Abramidze T, Kvachadze I, Karsanidze L, Kiladze M, Dolidze N, Leupold W, Keil U, von Mutius E, Weiland SK, Arthur P, Addo-Yobo E, Gratziou C, Priftis K, Papadopoulou A, Katsardis C, Tsanakas J, Hatziagorou E, Kirvassilis F, Clausen M, Shah JR, Mathur RS, Khubchandani RP, Mantri S, Forastiere F, Di Domenicantonio R, De Sario M, Sammarro S, Pistelli R, Serra MG, Corbo G, Perucci CA, Svabe V, Sebre D, Casno G, Novikova I, Bagrade L, Brunekreef B, Schram D, Doekes G, Jansen-van Vliet PH, Janssen NA, Aarts FJ, de Meer G, Crane J, Wickens K, Barry D, Nystad W, Bolle R, Lund E, Batlles Garrido J, Rubi Ruiz T, Bonillo Perales A, Gonzalez Jiménez Y, Aguirre Rodriguez J, Momblan de Cabo J, Losilla Maldonado A, Daza Torres M, García-Marcos L, Martinez Torres A, Guillén Pérez JJ, Piñana López A, Castejon Robles S, García Hernandez G, Martinez Gimeno A, Moro Rodríguez AL, Luna Paredes C, Gonzalez Gil I, Morales Suarez-Varela MM, Llopis González A, Escribano Montaner A, Tallon Guerola M, Bråbäck L, Sandin A, Kjellman M, Nilsson L, Mai XM, Saraçlar Y, Tuncer A, Saçkesen C, Sumbulglu V, Geyik P, Kocabas C, Kuyucu S, Strachan DP, Kaur B, El-Sharif N, Barghuthy F, Abu Huij S, Qlebo M, Nemery B, Aït-Khaled N, Anderson HR, Pearce N, Strachan DP, Flohr C, Williams H, Forastiere F, Asher MI, Ellwood P, Stewart A, Mitchell E, Crane J, Beasley R, Björkstén B, Brunekreef B, Foliaki S, García-Marcos L, von Mutius E, Keil U, Weiland SK, Weinmayr G, Lai CK, Wong GW, Mallol J, Montefort S, Odhiambo J, Robertson C.

Author information

Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Division of Community Health Sciences, St. Georges', University of London, London, United Kingdom.



Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated.


Cross-sectional studies of stratified random samples of 8-12-year-old children (n = 10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated.


Overweight (odds ratio = 1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio = 1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, -0.90, 95%-confidence interval: -1.33%; -0.47%, for overweight and -2.46%, 95%-confidence interval: -3.84%; -1.07%, for obesity) whereas the results for the other objective markers, including atopy, were null.


Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center