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Nat Med. 2014 Dec;20(12):1386-93. doi: 10.1038/nm.3764.

An emerging consensus on cardiac regeneration.

Author information

1
Lillehei Heart Institute, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
2
1] Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. [2] Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Abstract

Cardiac regeneration is a rapidly evolving and controversial field of research. The identification some 12 years ago of progenitor cells that reside within the heart spurred enthusiasm for cell-based regenerative therapies. However, recent evidence has called into question both the presence of a biologically important stem cell population in the heart and the ability of exogenously derived cells to promote regeneration through direct formation of new cardiomyocytes. Here, we discuss recent developments that suggest an emerging consensus on the ability of different cell types to regenerate the adult mammalian heart.

PMID:
25473919
PMCID:
PMC4418535
DOI:
10.1038/nm.3764
[Indexed for MEDLINE]
Free PMC Article

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