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Respirol Case Rep. 2014 Jun;2(2):87-9. doi: 10.1002/rcr2.58. Epub 2014 May 4.

Two sequential tPA/DNase courses for noncommunicating loculated collections in pleural infection.

Author information

1
Pharmacy Department, Sir Charles Gairdner Hospital Perth, Western Australia, Australia ; Centre for Asthma, Allergy & Respiratory Research, School of Medicine & Pharmacology, University of Western Australia Perth, Western Australia, Australia.
2
Department of Medicine, Swan District Hospital Perth, Western Australia, Australia.
3
Department of Respiratory Medicine, Sir Charles Gairdner Hospital Perth, Western Australia, Australia.
4
Centre for Asthma, Allergy & Respiratory Research, School of Medicine & Pharmacology, University of Western Australia Perth, Western Australia, Australia ; Department of Respiratory Medicine, Sir Charles Gairdner Hospital Perth, Western Australia, Australia.

Abstract

Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is being increasingly employed as an alternative to surgical intervention for the treatment of complicated parapneumonic effusions and empyema. Published cases are limited to one randomized control trial and few case reports. No data exist on employing sequential or repeated courses of intrapleural tPA/DNase to aid evacuation of separate collections in patients' with a multiloculated pleural infection. This is the first report of successful use of sequential delivery of separate courses of intrapleural tPA/DNase to two noncommunicating infected pleural fluid collections within the same hemithorax of a patient. Our case confirms that prior treatment with tPA/DNase therapy does not preclude subsequent effective and safe use of this intrapleural treatment.

KEYWORDS:

Deoxyribonuclease; empyema; fibrinolytics; pleural infection; tissue plasminogen activator

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