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Ann Dermatol. 2014 Dec;26(6):733-8. doi: 10.5021/ad.2014.26.6.733. Epub 2014 Nov 26.

Clinical Evaluation of a New-Formula Shampoo for Scalp Seborrheic Dermatitis Containing Extract of Rosa centifolia Petals and Epigallocatechin Gallate: A Randomized, Double-Blind, Controlled Study.

Author information

1
Department of Dermatology, Konkuk University School of Medicine, Konkuk University, Seoul, Korea.
2
AmorePacific R&D Center, Yongin, Korea.
3
Department of Dermatology, Konkuk University School of Medicine, Konkuk University, Seoul, Korea. ; Research Institute of Medical Science, Konkuk University, Seoul, Korea.

Abstract

BACKGROUND:

Scalp seborrheic dermatitis is a chronic type of inflammatory dermatosis that is associated with sebum secretion and proliferation of Malassezia species. Ketoconazole or zinc-pyrithione shampoos are common treatments for scalp seborrheic dermatitis. However, shampoos comprising different compounds are required to provide patients with a wider range of treatment options.

OBJECTIVE:

This study was designed to evaluate a new-formula shampoo that contains natural ingredients-including extract of Rosa centifolia petals and epigallocatechin gallate (EGCG)-that exert antioxidative, anti-inflammatory, and sebum secretion inhibitory effects, and antifungal agents for the treatment of scalp seborrheic dermatitis.

METHODS:

Seventy-five patients were randomized into three treatment groups; new-formula shampoo, 2% ketoconazole shampoo, and 1% zinc- pyrithione shampoo. The clinical severity scores and sebum levels were assessed by the same dermatologists at baseline (week 0), and at 2 and 4 weeks after using the shampoo. User satisfaction and irritation were also assessed with the aid of a questionnaire.

RESULTS:

The efficacy of the new-formula shampoo was comparable to that of both the 1% zinc-pyrithione shampoo and the 2% ketoconazole shampoo. Furthermore, it was found to provide a more rapid response than the 1% zinc-pyrithione shampoo for mild erythema lesions and was associated with greater user satisfaction compared with the 2% ketoconazole shampoo. However, the new-formula shampoo did not exhibit the previously reported sebum inhibitory effect.

CONCLUSION:

Extract of R. centifolia petals or EGCG could be useful ingredients in the treatment of scalp seborrheic dermatitis.

KEYWORDS:

Ellagitannins; Epigallocatechin gallate; Ketoconazole; Seborrheic dermatitis; Zinc pyrithione

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