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Res Virol. 1989 May-Jun;140(3):219-28.

In vitro sensitivity of human herpesvirus-6 to antiviral drugs.

Author information

1
Laboratoire de Bactériologie-Virologie, CERVI, Hôpital de la Pitié-Salpêtrière, Paris.

Abstract

We studied the sensitivity of human herpesvirus-6 (HHV-6) to 4 antiviral drugs known to be effective in the treatment of infections with other human herpesviruses and human immunodeficiency virus. HHV-6 was grown in peripheral blood lymphocytes, and virus multiplication was quantified by evaluation of the cytopathic effect by molecular hybridization and indirect immunofluorescence assay. The 50% and 90% inhibitory concentrations (IC50 and IC90) were determined for each drug. The results obtained by the 3 different quantification techniques were found to correlate, and enabled us to conclude that HHV-6 replication was readily inhibited by foscarnet or ganciclovir. In contrast, inhibition of HHV-6 replication was observed only at high concentrations of acyclovir, and was not detected at the tested concentrations of zidovudine.

PMID:
2547238
DOI:
10.1016/s0923-2516(89)80099-8
[Indexed for MEDLINE]

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