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Development. 2014 Dec;141(24):4784-93. doi: 10.1242/dev.108290.

The role of T-cadherin in axonal pathway formation in neocortical circuits.

Author information

1
Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
2
Department of Biology, Aichi Medical University, Karimata-Yazako, Nagakute, Aichi 480-1195, Japan.
3
Laboratories of Biomolecular Networks, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
4
Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan nobuhiko@fbs.osaka-u.ac.jp.

Abstract

Cortical efferent and afferent fibers are arranged in a stereotyped pattern in the intermediate zone (IZ). Here, we studied the mechanism of axonal pathway formation by identifying a molecule that is expressed in a subset of cortical axons in the rat. We found that T-cadherin (T-cad), a member of the cadherin family, is expressed in deep-layer cell axons projecting to subcortical structures, but not in upper layer callosal axons projecting to the contralateral cortex. Ectopic expression of T-cad in upper layer cells induced axons to project toward subcortical structures via the upper part of the IZ. Moreover, the axons of deep-layer cells in which T-cad expression was suppressed by RNAi projected towards the contralateral cortex via an aberrant route. These results suggest that T-cad is involved in axonal pathway formation in the developing cortex.

KEYWORDS:

Adhesion; Cadherin; Fasciculation; Neocortex; Pathfinding

PMID:
25468941
DOI:
10.1242/dev.108290
[Indexed for MEDLINE]
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