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Trends Biochem Sci. 2015 Jan;40(1):1-3. doi: 10.1016/j.tibs.2014.10.010. Epub 2014 Nov 23.

The utility of protein and mRNA correlation.

Author information

1
Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99354, USA. Electronic address: samuel.payne@pnnl.gov.

Abstract

Transcriptomic, proteomic, and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however, the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.

KEYWORDS:

bioinformatics; proteomics; systems biology; transcriptomics

PMID:
25467744
PMCID:
PMC4776753
DOI:
10.1016/j.tibs.2014.10.010
[Indexed for MEDLINE]
Free PMC Article

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