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Cancer Treat Rev. 2015 Jan;41(1):1-8. doi: 10.1016/j.ctrv.2014.10.008. Epub 2014 Nov 6.

Beyond BRCA: new hereditary breast cancer susceptibility genes.

Author information

1
Oncology Unit, 2nd Department of Internal Medicine, Attikon University Hospital, National Kapodistrian University of Athens, Greece. Electronic address: panagiota_oiko@hotmail.com.
2
Oncology Unit, 2nd Department of Internal Medicine, Attikon University Hospital, National Kapodistrian University of Athens, Greece.

Abstract

Approximately 5-10% of breast cancer cases might be inheritable, up to 30% of which are due to BRCA1/2 mutations. During the past few years and thanks to technology evolution, we have been witnesses of an intensive search of additional genes with similar characteristics, under the premise that successful gene discovery will provide substantial opportunities for primary and secondary prevention of breast cancer. Consequently, new genes have emerged as breast cancer susceptibility genes, including rare germline mutations in high penetrant genes, such as TP53 and PTEN, and more frequent mutations in moderate penetrant genes, such as CHEK2, ATM and PALB2. This review will summarize current data on new findings in breast cancer susceptibility genes.

KEYWORDS:

Breast cancer susceptibility genes; Hereditary breast cancer; PALB2; PTEN; TP53

PMID:
25467110
DOI:
10.1016/j.ctrv.2014.10.008
[Indexed for MEDLINE]

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