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Nat Rev Mol Cell Biol. 2015 Jan;16(1):57-64. doi: 10.1038/nrm3916. Epub 2014 Dec 3.

Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.

Author information

1
Department of Biochemistry, The Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire 03755, USA, and at the Norris Cotton Cancer Center, Lebanon, New Hampshire 03766, USA.

Abstract

Faithful chromosome segregation during mitosis is essential for genome integrity and is mediated by the bi-oriented attachment of replicated chromosomes to spindle microtubules through kinetochores. Errors in kinetochore-microtubule (k-MT) attachment that could cause chromosome mis-segregation are frequent and are corrected by the dynamic turnover of k-MT attachments. Thus, regulating the rate of spindle microtubule attachment and detachment to kinetochores is crucial for mitotic fidelity and is frequently disrupted in cancer cells displaying chromosomal instability. A model based on homeostatic principles involving receptors, a core control network, effectors and feedback control may explain the precise regulation of k-MT attachment stability during mitotic progression to ensure error-free mitosis.

PMID:
25466864
PMCID:
PMC4568440
DOI:
10.1038/nrm3916
[Indexed for MEDLINE]
Free PMC Article

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