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Cell Rep. 2014 Dec 11;9(5):1574-1583. doi: 10.1016/j.celrep.2014.10.068. Epub 2014 Nov 26.

Adipocyte-specific IKKβ signaling suppresses adipose tissue inflammation through an IL-13-dependent paracrine feedback pathway.

Author information

1
Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2
Department of Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3
Department of Surgery, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4
Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: jeffrey.pessin@einstein.yu.edu.

Abstract

Adipose tissue inflammation is one pathway shown to mediate insulin resistance in obese humans and rodents. Obesity induces dynamic cellular changes in adipose tissue to increase proinflammatory cytokines and diminish anti-inflammatory cytokines. However, we have found that anti-inflammatory interleukin-13 (IL-13) is unexpectedly induced in adipose tissue of obese humans and high-fat diet (HFD)-fed mice, and the source of IL-13 is primarily the adipocyte. Moreover, HFD-induced proinflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and IL-1β mediate IL-13 production in adipocytes in an IKKβ-dependent manner. In contrast, adipocyte-specific IKKβ-deficient mice show diminished IL-13 expression and enhanced inflammation after HFD feeding, resulting in a worsening of the insulin-resistant state. Together these data demonstrate that although IKKβ activates the expression of proinflammatory mediators, in adipocytes, IKKβ signaling also induces the expression of the anti-inflammatory cytokine IL-13, which plays a unique protective role by limiting adipose tissue inflammation and insulin resistance.

PMID:
25466256
PMCID:
PMC4268106
DOI:
10.1016/j.celrep.2014.10.068
[Indexed for MEDLINE]
Free PMC Article

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