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Braz J Med Biol Res. 2015 Feb;48(2):174-7. doi: 10.1590/1414-431X20144154. Epub 2014 Dec 5.

Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates.

Author information

1
Laboratório Especial de Microbiologia Clínica, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
2
Laboratório Diagnósticos da América, DASA, São Paulo, SP, Brasil.

Abstract

We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (blaNDM-1)-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. blaNDM-1 was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (blaKPC-2) or aminoglycoside-resistance methylase (armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of blaNDM-1 in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship.

PMID:
25466163
PMCID:
PMC4321224
DOI:
10.1590/1414-431X20144154
[Indexed for MEDLINE]
Free PMC Article

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