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Food Chem. 2015 Apr 15;173:1187-94. doi: 10.1016/j.foodchem.2014.10.152. Epub 2014 Nov 7.

The intake of broccoli sprouts modulates the inflammatory and vascular prostanoids but not the oxidative stress-related isoprostanes in healthy humans.

Author information

1
Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Espinardo, Murcia, Spain.
2
Breast Pathology Unit, Hospital José María Morales Meseguer, Avda. Marqués de los Vélez, s/n, Murcia, Spain.
3
Department of Food Science and Technology, CEBAS-CSIC, P.O. Box 164, 30100 Espinardo, Murcia, Spain. Electronic address: angelgil@cebas.csic.es.

Abstract

Current evidence supports the positive association between the consumption of plant foods and health. In this work, we assessed the effect of consuming a half-serving (30 g) or one serving (60 g) of broccoli sprouts on the urinary concentrations of biomarkers of oxidative stress (isoprostanes) and inflammation (prostaglandins and thromboxanes). Twenty-four volunteers participated in the project. A quantitative determination of sulforaphane and its mercapturic derivatives, eicosanoids, and total vitamin C in urine was performed. The intake of broccoli sprouts produced an increase in the urinary concentrations of sulforaphane metabolites and vitamin C. Among the 13 eicosanoids analyzed, tetranor-PGEM and 11β-PGF2α as well as 11-dehydro-TXB2 showed a significant decrease in their urinary concentrations after the ingestion of broccoli sprouts. Therefore, the consumption of broccoli sprouts modulated the excretion of biomarkers linked to inflammation and vascular reactions without exerting a significant influence on the oxidation of phospholipids in vivo.

KEYWORDS:

Broccoli; Eicosanoids; Oxidative stress; Sulforaphane; Urine; Vitamin C

PMID:
25466142
DOI:
10.1016/j.foodchem.2014.10.152
[Indexed for MEDLINE]

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