Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Calcium. 2015 Jul;58(1):105-13. doi: 10.1016/j.ceca.2014.10.009. Epub 2014 Oct 29.

Flagellar ion channels of sperm: similarities and differences between species.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States; Department of Physiology, University of California, San Francisco, CA 94158, United States.
2
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States.
3
Department of Anatomy, Physiology & Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
4
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States. Electronic address: lishko@berkeley.edu.

Abstract

Motility and fertilization potential of mammalian sperm are regulated by ion homeostasis which in turn is under tight control of ion channels and transporters. Sperm intracellular pH, membrane voltage and calcium concentration ([Ca(2+)]i) are all important for sperm activity within the female reproductive tract. While all mammalian sperm are united in their goal to find and fertilize an egg, the molecular mechanisms they utilize for this purpose are diverse and differ between species especially on the level of ion channels. Recent direct recording from sperm cells of different species indicate the differences between rodent, non-human primate, ruminant, and human sperm on the basic levels of their ion channel regulation. In this review we summarize the current knowledge about ion channel diversity of the animal kingdom and concentrate our attention on flagellar ion channels of mammalian sperm.

KEYWORDS:

Capacitation; CatSper; Fertilization; Flagellar calcium channel; Hv1; Hyperactivation; KSper; Non-genomic progesterone signaling; Slo1; Slo3; Sperm ion channels

PMID:
25465894
DOI:
10.1016/j.ceca.2014.10.009
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for eScholarship, California Digital Library, University of California
    Loading ...
    Support Center