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J Cataract Refract Surg. 2014 Dec;40(12):1985-93. doi: 10.1016/j.jcrs.2014.03.030. Epub 2014 Nov 24.

Central toxic keratopathy after laser in situ keratomileusis.

Author information

1
From the Cornea and Refractive Surgery Service (Jutley, Aiello, Robaei, Maurino), Moorfields Eye Hospital, NHS Trust, London, United Kingdom, and the Department of Experimental Medicine (Aiello), Ophthalmology Unit, University of Rome Tor Vergata, Rome, Italy.
2
From the Cornea and Refractive Surgery Service (Jutley, Aiello, Robaei, Maurino), Moorfields Eye Hospital, NHS Trust, London, United Kingdom, and the Department of Experimental Medicine (Aiello), Ophthalmology Unit, University of Rome Tor Vergata, Rome, Italy. Electronic address: vincenzo.maurino@moorfields.nhs.uk.

Abstract

PURPOSE:

To review cases of central toxic keratopathy (CTK) occurring over a period of 46 days.

SETTING:

Moorfields Eye Hospital, London, United Kingdom.

DESIGN:

Retrospective consecutive case series.

METHODS:

This was a review of patients with CTK after uneventful laser in situ keratomileusis (LASIK) performed by 1 of 5 surgeons at a single institute. The following parameters were analyzed: corrected distance visual acuity (CDVA), manifest refraction, and central corneal thickness from Scheimpflug pachymetry readings (Pentacam).

RESULTS:

The cohort consisted of 15 eyes of 9 patients. Thirteen eyes were diagnosed within 7 days after LASIK, while the remaining 2 eyes developed CTK 12 days postoperatively. In 10 eyes, the time to resolution was 1 to 8 months. Five eyes still had residual signs at the last outpatient visit. At the final follow-up, 3 eyes (20%) had a CDVA worse than 0.0 logMAR.

CONCLUSIONS:

Although a rare entity, CTK can occur in clusters. Although a cause was not fully isolated, ultimately each eye achieved excellent CDVA (all better than 0.2 logMAR) at the last follow-up.

PMID:
25465684
DOI:
10.1016/j.jcrs.2014.03.030
[Indexed for MEDLINE]

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