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Obes Res Clin Pract. 2015 Mar-Apr;9(2):180-3. doi: 10.1016/j.orcp.2014.10.221. Epub 2014 Nov 18.

The association between body composition and cystatin C in South Asians: results from the MASALA study.

Author information

1
Division of Endocrinology and Metabolism, University of California, San Francisco, United States. Electronic address: Arti.Shah@ucsf.edu.
2
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, United States.
3
Department of Epidemiology and Biostatistics, University of California, San Francisco, United States.
4
Department of Epidemiology and Biostatistics, University of California, San Francisco, United States; Division of General Internal Medicine, San Francisco Veterans Affairs Medical Center, United States.
5
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, United States; Department of Epidemiology and Biostatistics, University of California, San Francisco, United States.

Abstract

While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFRcysC) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFRcysC was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation.

KEYWORDS:

Body composition; Cystatin C; Ectopic fat; South Asian

PMID:
25465493
PMCID:
PMC4404210
DOI:
10.1016/j.orcp.2014.10.221
[Indexed for MEDLINE]
Free PMC Article

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