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Curr Opin Cell Biol. 2015 Apr;33:19-25. doi: 10.1016/j.ceb.2014.10.006. Epub 2014 Nov 12.

Cell cycle regulation of mitochondrial function.

Author information

1
Department of Physiology, Université de Lausanne, Lausanne CH-1005, Switzerland.
2
Department of Physiology, Université de Lausanne, Lausanne CH-1005, Switzerland. Electronic address: lluis.fajas@unil.ch.

Abstract

Specific cellular functions, such as proliferation, survival, growth, or senescence, require a particular adaptive metabolic response, which is fine tuned by members of the cell cycle regulators families. Currently, proteins such as cyclins, CDKs, or E2Fs are being studied in the context of cell proliferation and survival, cell signaling, cell cycle regulation, and cancer. We show in this review that cellular, animal and molecular studies provided enough evidence to prove that these factors play, in addition, crucial roles in the control of mitochondrial function; finally resulting in a dual proliferative and metabolic response.

PMID:
25463842
DOI:
10.1016/j.ceb.2014.10.006
[Indexed for MEDLINE]

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