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Clin Chim Acta. 2015 Mar 30;443:114-9. doi: 10.1016/j.cca.2014.11.020. Epub 2014 Nov 22.

Micro-RNAs and next generation sequencing: new perspectives in heart failure.

Author information

  • 1Qatar Biomedical Research Institute (QBRI), Medical Genetics Center, 69 Lusail Street, 33123 Doha, Qatar. Electronic address: vchini@qf.org.qa.

Abstract

miRNAs are small non-coding RNAs that regulate gene expression. They have significant role in the regulation of cardiovascular function and conditions, such as Heart Failure (HF), as demonstrated by studies of miRNA expression profiling in myocardial tissue. The importance of the use of miRNAs as biomarkers in HF was enhanced when found that they exist extracellularly, with remarkable stability and there are indications that their expression levels reflect the cell response in cardiovascular conditions including Heart Failure. Advances in technology and bioinformatics broaden the field of applications of miRNAs in HF. The introduction of new platforms, such as Next Generation Sequencing, enabled the discovery of novel miRNAs that might be utilized as Heart Failure biomarkers for diagnostic and prognostic purposes and with potential applications in targeted therapeutics.

KEYWORDS:

Heart Failure; Next Generation Sequencing; miRNA

PMID:
25463748
DOI:
10.1016/j.cca.2014.11.020
[PubMed - indexed for MEDLINE]
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