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Reprod Toxicol. 2015 Jan;51:22-30. doi: 10.1016/j.reprotox.2014.11.005. Epub 2014 Nov 22.

Interaction between paraoxonase 1 polymorphism and prenatal pesticide exposure on metabolic markers in children using a multiplex approach.

Author information

1
Institute of Public Health, University of Southern Denmark, Odense, Denmark; University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
2
National Food Institute, Division of Toxicology and Risk Assessment, Technical University of Denmark, Søborg, Denmark.
3
University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
4
Institute of Public Health, University of Southern Denmark, Odense, Denmark.
5
Institute of Public Health, University of Southern Denmark, Odense, Denmark. Electronic address: hrandersen@health.sdu.dk.

Abstract

Prenatal environmental exposures may influence the risk of cardio-metabolic diseases later in life. This study used a multiplex approach to investigate non-fasting serum levels of metabolic markers in a cohort of school-aged children for whom associations between prenatal pesticide exposure and body fat content and blood pressure were previously found to be dependent on paraoxonase1 (PON1) Q192R genotype. In children with the PON1 192 R-allele, leptin, glucagon, and plasminogen activator inhibitor-1 (PAI-1) were positively associated with prenatal pesticide exposure. For PON1 192 QQ-homozygote children none of the biomarkers were significantly affected by prenatal pesticide exposure. In children with the R-allele, leptin was associated with both body fat measures and prenatal pesticide exposure and seems to mediate body fat accumulation in exposed children. These findings support our previous results of an adverse cardio-metabolic risk profile associated with prenatal pesticide exposure in children with the PON1 192 R-allele.

KEYWORDS:

Environmental obesogens; Glucagon; Leptin; PAI-1; Pesticides, Prenatal exposure, PON1 genotype

PMID:
25463530
DOI:
10.1016/j.reprotox.2014.11.005
[Indexed for MEDLINE]

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