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Environ Res. 2014 Nov;135:285-8. doi: 10.1016/j.envres.2014.09.016. Epub 2014 Oct 14.

Within-person variability of urinary bisphenol-A in postmenopausal women.

Author information

  • 1Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA. Electronic address:
  • 2Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.
  • 3Division of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA.
  • 4Department of Applied Health Science, Indiana University, Bloomington, IN, USA.
  • 5HealthPartners Institute for Education and Research, University of Minnesota, Minneapolis, MN, USA.
  • 6Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • 7Analytical Biochemistry Shared Resource, University of Hawaii Cancer Center, Honolulu, HI, USA.


We evaluated the within-person variability of urinary BPA levels over two samples collected three years apart in 90 Women's Health Initiative participants. The intraclass correlation coefficient was 0.09 (95% CI 0.01-0.44), indicating high within-participant variability relative to the between-person variation. Concordance of BPA quartile over time was low (31.7%) and was unrelated to demographic, behavioral, or dietary factors. A single, or even several, measurements of BPA may not adequately classify long-term exposure in human studies.


Bisphenol-A; Exposure measurement; Postmenopausal; Variability; Women

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