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Curr Opin Virol. 2014 Dec;9:127-33. doi: 10.1016/j.coviro.2014.09.016. Epub 2014 Oct 17.

Evidence linking HHV-6 with multiple sclerosis: an update.

Author information

1
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Institute for Biomedical Sciences, School of Medicine and Health Sciences of The George Washington University, Washington, DC, USA.
2
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: jacobsons@ninds.nih.gov.

Abstract

Following reports of elevated antiviral antibodies in MS patient sera and viral DNA detection in MS plaques nearly two decades ago, the neurovirology community has actively explored how herpesviruses such as HHV-6 might be involved in MS disease pathogenesis. Though findings across the field are non-uniform, an emerging consensus of viral correlates with disease course and evidence of HHV-6-specific immune responses in the CNS provide compelling evidence for a role, direct or indirect, of this virus in MS. Ultimately, the only way to demonstrate the involvement, or lack thereof, of HHV-6 or other herpesviruses in this disease is through a controlled clinical trial of an efficacious antiviral drug.

PMID:
25462444
PMCID:
PMC4269240
DOI:
10.1016/j.coviro.2014.09.016
[Indexed for MEDLINE]
Free PMC Article

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