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Curr Opin Virol. 2014 Dec;9:74-83. doi: 10.1016/j.coviro.2014.09.011. Epub 2014 Oct 17.

Regulation of Flavivirus RNA synthesis and replication.

Author information

1
Aix-Marseille Université, AFMB UMR 7257, 13288 Marseille, France; CNRS, AFMB UMR 7257, 13288 Marseille, France.
2
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, Berkeley, CA 94720-3370, USA.
3
Aix-Marseille Université, AFMB UMR 7257, 13288 Marseille, France; CNRS, AFMB UMR 7257, 13288 Marseille, France. Electronic address: Bruno.Canard@afmb.univ-mrs.fr.

Abstract

RNA synthesis and replication of the members of the Flavivirus genus (including dengue, West Nile and Japanese encephalitis viruses) is regulated by a wide variety of mechanisms and actors. These include the sequestration of the RNA-dependent RNA polymerase (RdRp) for functions other than RNA synthesis, regulatory interactions with other viral and host proteins within the replication complex (RC), and regulatory elements within the RNA genome itself. In this review, we discuss our current knowledge of the multiple levels at which Flavivirus RNA synthesis is controlled. We aim to bring together two active research fields: the structural and functional biology of individual proteins of the RC and the impressive wealth of knowledge acquired regarding the viral genomic RNA.

PMID:
25462437
PMCID:
PMC4295515
DOI:
10.1016/j.coviro.2014.09.011
[Indexed for MEDLINE]
Free PMC Article

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