Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Pharmacol. 2015 Feb;20:35-9. doi: 10.1016/j.coph.2014.11.005. Epub 2014 Nov 25.

How does ketamine elicit a rapid antidepressant response?

Author information

1
Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390-9111, USA; Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: ege.kavalali@utsouthwestern.edu.
2
Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: lisa.monteggia@utsouthwestern.edu.

Abstract

A single sub-psychotomimetic dose of ketamine, an ionotropic glutamatergic n-methyl-D-aspartate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients suffering from major depressive disorder. Depressed patients report alleviation of core symptoms within 2 h of a single low-dose intravenous infusion of ketamine with effects lasting up to 2 weeks. The rapidity of ketamine action implies that major symptoms of depression can be alleviated without substantial structural plasticity or circuit rewiring. Therefore, the ability of ketamine to exert a rapid effect provides a unique opportunity to elucidate the types of acute synaptic plasticity changes that can be recruited to counter depression symptoms.

PMID:
25462290
PMCID:
PMC4318725
DOI:
10.1016/j.coph.2014.11.005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center