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Biochim Biophys Acta. 2015 Sep;1853(9):1980-91. doi: 10.1016/j.bbamcr.2014.11.023. Epub 2014 Nov 25.

Structural insights into endoplasmic reticulum stored calcium regulation by inositol 1,4,5-trisphosphate and ryanodine receptors.

Author information

1
Department of Molecular Science and Technology, Ajou University, Suwon, Gyeonggi 443-749, Republic of Korea; College of Pharmacy, Ajou University, Suwon, Gyeonggi 443-749, Republic of Korea.
2
Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5G 1L7, Canada.
3
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.
4
Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: mikura@uhnres.utoronto.ca.

Abstract

The two major calcium (Ca²⁺) release channels on the sarco/endoplasmic reticulum (SR/ER) are inositol 1,4,5-trisphosphate and ryanodine receptors (IP3Rs and RyRs). They play versatile roles in essential cell signaling processes, and abnormalities of these channels are associated with a variety of diseases. Structural information on IP3Rs and RyRs determined using multiple techniques including X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy and cryo-electron microscopy (EM), has significantly advanced our understanding of the mechanisms by which these Ca²⁺ release channels function under normal and pathophysiological circumstances. In this review, structural advances on the understanding of the mechanisms of IP3R and RyR function and dysfunction are summarized. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.

KEYWORDS:

Calcium release channel; Calcium signaling; Electron microscopy (EM); Inositol 1,4,5-trisphosphate receptor (IP(3)R); Nuclear magnetic resonance (NMR); Protein structure; Ryanodine receptor (RyR); X-ray crystallography

PMID:
25461839
DOI:
10.1016/j.bbamcr.2014.11.023
[Indexed for MEDLINE]
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