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Curr Opin Microbiol. 2015 Feb;23:121-5. doi: 10.1016/j.mib.2014.11.010. Epub 2014 Dec 2.

The rest of the story: the microbiome and gastrointestinal infections.

Author information

1
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
2
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address: youngvi@umich.edu.

Abstract

Bacterial infectious diseases are studied primarily as a host-pathogen dyad. However it is increasingly apparent that the gut microbial community is an important participant in these interactions. The gut microbiota influences bacterial infections in a number of ways, including via bacterial metabolism, stimulation of host immunity and direct bacterial antagonism. This review focuses on recent findings highlighting the interplay between the gastrointestinal microbiota, its host and bacterial pathogens; and emphasizes how these interactions ultimately impact our understanding of infectious diseases.

PMID:
25461582
PMCID:
PMC4324160
DOI:
10.1016/j.mib.2014.11.010
[Indexed for MEDLINE]
Free PMC Article

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