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Curr Opin Microbiol. 2015 Feb;23:94-101. doi: 10.1016/j.mib.2014.11.009. Epub 2014 Nov 27.

Microbial pathogenesis and host defense in the nematode C. elegans.

Author information

1
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
2
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States. Electronic address: etroemel@ucsd.edu.

Abstract

Epithelial cells line the surfaces of the body, and are on the front lines of defense against microbial infection. Like many other metazoans, the nematode Caenorhabditis elegans lacks known professional immune cells and relies heavily on defense mediated by epithelial cells. New results indicate that epithelial defense in C. elegans can be triggered through detection of pathogen-induced perturbation of core physiology within host cells and through autophagic defense against intracellular and extracellular pathogens. Recent studies have also illuminated a diverse array of pathogenic attack strategies used against C. elegans. These findings are providing insight into the underpinnings of host/pathogen interactions in a simple animal host that can inform studies of infectious diseases in humans.

PMID:
25461579
PMCID:
PMC4324121
DOI:
10.1016/j.mib.2014.11.009
[Indexed for MEDLINE]
Free PMC Article

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