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Curr Opin Microbiol. 2015 Feb;23:86-93. doi: 10.1016/j.mib.2014.11.008. Epub 2014 Nov 27.

Legionella pneumophila: homeward bound away from the phagosome.

Author information

1
Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
2
Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5. Electronic address: terebiznik@utsc.utoronto.ca.

Abstract

The intracellular pathogen Legionella pneumophila (Lp) survives and replicates inside a specialized vacuolar compartment that evades canonical phagosomal maturation. Through the action of a large number of effectors translocated into the host cytosol via the Dot/Icm type IV secretion system, Lp subverts host cell pathways to convert its nascent phagosome into an ER-derived compartment, the Legionella containing vacuole (LCV), which serves as bacterial replication niche.

PMID:
25461578
DOI:
10.1016/j.mib.2014.11.008
[Indexed for MEDLINE]

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