Format

Send to

Choose Destination
Curr Opin Microbiol. 2015 Feb;23:80-5. doi: 10.1016/j.mib.2014.11.007. Epub 2014 Nov 26.

New insights into the role of Bartonella effector proteins in pathogenesis.

Author information

1
Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland.
2
Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland. Electronic address: christoph.dehio@unibas.ch.

Abstract

The facultative intracellular bacteria Bartonella spp. share a common infection strategy to invade and colonize mammals in a host-specific manner. Following transmission by blood-sucking arthropods, Bartonella are inoculated in the derma and then spread, via two sequential enigmatic niches, to the blood stream where they cause a long-lasting intra-erythrocytic bacteraemia. The VirB/VirD4 type IV secretion system (VirB/D4 T4SS) is essential for the pathogenicity of most Bartonella species by injecting an arsenal of effector proteins into host cells. These bacterial effector proteins share a modular architecture, comprising domains and/or motifs that confer an array of functions. Here, we review recent advances in understanding the function and evolutionary origin of this fascinating repertoire of host-targeted bacterial effectors.

PMID:
25461577
DOI:
10.1016/j.mib.2014.11.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center