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Curr Opin Microbiol. 2015 Feb;23:14-22. doi: 10.1016/j.mib.2014.10.009. Epub 2014 Nov 13.

Targeting of plant pattern recognition receptor-triggered immunity by bacterial type-III secretion system effectors.

Author information

1
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
2
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom. Electronic address: cyril.zipfel@tsl.ac.uk.

Abstract

During infection, microbes are detected by surface-localized pattern recognition receptors (PRRs), leading to an innate immune response that prevents microbial ingress. Therefore, successful pathogens must evade or inhibit PRR-triggered immunity to cause disease. In the past decade, a number of type-III secretion system effector (T3Es) proteins from plant pathogenic bacteria have been shown to suppress this layer of innate immunity. More recently, the detailed mechanisms of action have been defined for several of these effectors. Interestingly, effectors display a wide array of virulence targets, being able to prevent activation of immune receptors and to hijack immune signaling pathways. Besides being a fascinating example of pathogen-host co-evolution, effectors have also emerged as valuable tools to dissect important biological processes in host cells.

PMID:
25461568
DOI:
10.1016/j.mib.2014.10.009
[Indexed for MEDLINE]

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