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Environ Toxicol Pharmacol. 2014 Nov;38(3):838-44. doi: 10.1016/j.etap.2014.09.004. Epub 2014 Sep 16.

Immunotoxicity effects of carbaryl in vivo and in vitro.

Author information

1
Fatemeh Zahra Infertility Research Center, Babol University of Medical Sciences, Babol, Iran.
2
Department of Immunology, Babol University of Medical Sciences, Babol, Iran.
3
Department of Immunology, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address: azadmehr2014@gmail.com.
4
Department of Pharmacology and Physiology, Babol University of Medical Sciences, Babol, Iran.
5
Medical School, Babol University of Medical Sciences, Babol, Iran.

Abstract

Carbaryl is a pesticide for controlling pests in agricultural industry. To determine of immunotoxicity effects of carbaryl, rats were exposure with carbaryl for 28 days. The lymphoid organ weight, lymphocyte proliferation, IL-2, IFN-γ, IL-4, IL-10, IL-1β and TNF-α cytokines level were measured, respectively. Exposure with carbaryl significantly reduced both thymus and spleen weight and also suppressed lymphocyte proliferation. In addition, carbaryl significantly decreased IL-2, IFN-γ, IL-1β and TNF-α and also increased IL-4, IL-10 cytokines. These findings suggest that exposure to carbaryl can induce immunotoxicity effects on lymphoid organ weight, suppresses the functions of lymphocyte and macrophage, Th2 polarization in Th1/Th2 balance by reducing of IFN-γ and increasing of IL-4 and IL-10 cytokines. Therefore, carbaryl can contribute to the development of allergic, autoimmune, cancer or infection diseases through immunotoxicity effects and unbalancing of Th1/Th2 immune response however, further study is necessary.

KEYWORDS:

Carbaryl; Cytokines; Immunotoxicity; Lymphocyte; Macrophage; Th1/Th2

PMID:
25461543
DOI:
10.1016/j.etap.2014.09.004
[Indexed for MEDLINE]

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