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Curr Opin Genet Dev. 2014 Oct;28:50-56. doi: 10.1016/j.gde.2014.09.006. Epub 2014 Oct 14.

Chemical approaches to cell reprogramming.

Yu C#1, Liu K#1, Tang S#1, Ding S1.

Author information

1
Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
#
Contributed equally

Abstract

Recent advances in cell reprogramming via employing different sets of factors, which allows generation of various cell types that are beyond the downstream developmental lineages from the starting cell type, provide significant opportunities to study fundamental biology and hold enormous promise in regenerative medicine. Small molecules have been identified to enhance and enable reprogramming by regulating various mechanisms, and provide a highly temporal and tunable approach to modulate cellular fate and functions. Here, we review the latest development in cell reprogramming from the perspective of small molecule modulation.

PMID:
25461450
PMCID:
PMC4747244
DOI:
10.1016/j.gde.2014.09.006
[Indexed for MEDLINE]
Free PMC Article

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