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Cytokine. 2015 Feb;71(2):132-8. doi: 10.1016/j.cyto.2014.09.012. Epub 2014 Oct 30.

Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: a randomized, double blind, placebo-controlled study.

Author information

1
The Physiology Research Laboratory, The Orthopedic Specialty Hospital, Murray, UT 84107, USA. Electronic address: tyler.barker@imail.org.
2
The Physiology Research Laboratory, The Orthopedic Specialty Hospital, Murray, UT 84107, USA.
3
Research and Development, USANA Health Sciences, Inc., Salt Lake City, UT 84120, USA.
4
Hyperbaric Medicine, Intermountain Medical Center, Murray, UT 84107, USA; LDS Hospital, Salt Lake City, UT 84143, USA; School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

Abstract

The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randomly assigned (double blind) to one of three groups: (1) placebo (n=15), or supplemental vitamin D (cholecalciferol) at (2) 4000 (n=14) or (3) 8000IU (n=17). Supplements were taken daily for 35days. Fasting blood samples were obtained before (Baseline, Bsl) and 35-days after (35-d) supplementation. Serum 25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)D), cytokines, and intact parathyroid hormone with calcium were measured in each blood sample. Supplemental vitamin D increased serum 25(OH)D (4000IU, ≈29%; 8000IU, ≈57%) and 1,25(OH)D (4000IU, ≈12%; 8000IU, ≈38%) without altering intact parathyroid hormone or calcium. The vitamin D metabolite increases in the supplemental vitamin D groups (n=31) were dependent on initial levels as serum 25(OH)D (r=-0.63, p<0.05) and 1,25(OH)D (r=-0.45, p<0.05) at Bsl correlated with their increases after supplementation. Supplemental vitamin D increased interferon (IFN)-γ and interleukin (IL)-10 in subjects that were vitamin D insufficient (serum 25(OH)D<29ng/mL) compared to sufficient (serum 25(OH)D⩾30ng/mL) at Bsl. We conclude that supplemental vitamin D increase a pro- and anti-inflammatory cytokine in those with initially low serum 25(OH)D.

KEYWORDS:

1,25-Dihydroxyvitamin D; Interferon-γ; Interleukin-10; Serum 25-hydroxyvitamin D

PMID:
25461390
DOI:
10.1016/j.cyto.2014.09.012
[Indexed for MEDLINE]

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