Format

Send to

Choose Destination
Eur J Obstet Gynecol Reprod Biol. 2014 Dec;183:121-4. doi: 10.1016/j.ejogrb.2014.10.021. Epub 2014 Oct 30.

Clinical factors and malignancy in endometrial polyps. Analysis of 1027 cases.

Author information

1
Department of Obstetrics, Gynecology and Urology, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy; Department of Obstetrics and Gynecology, Universitätsklinikum Freiburg, Freiburg i.Br., Germany. Electronic address: enzo.ricciardi@uniroma1.it.
2
Department of Pathology, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
3
Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Ferrara, Italy.
4
Department of Obstetrics, Gynecology and Urology, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.

Abstract

STUDY OBJECTIVE:

To assess the prevalence of polyps carrying a malignancy and match association between clinical factors and oncologic progression.

STUDY DESIGN:

A retrospective study (Canadian Task Force classification II-3) at a university hospital in Rome, Italy. We retrospectively analyzed data from 1027 women consecutively treated for endometrial polyps at our center in the period 2002-2011. The association of malignancy with hormonal status, tamoxifen, hypertension, symptoms, diabetes mellitus, obesity, and hormonal replacement therapy in pre- and post-menopausal women was assessed.

RESULTS:

Mean age was 45.8±10.8 years. Benign polyps accounted for 95.8% of the total, pre-malignant for 2.67%, malignant for 1.54%. Our data showed that post-menopausal and older women (>60y) with endometrial polyps have a higher risk of developing a related endometrial cancer (OR: 3.05, 95% CI [1.54, 6.19], p<0.001 and OR: 2.8, 95% CI [1.38, 5.56], p≤0.003. Also we observed that women with AUB in the post-menopausal period displayed a risk of malignancy (OR: 31.1, 95% CI [10.3,111], p value <0.001).

CONCLUSION:

Special attention should be drawn to symptomatic post-menopausal patients that appear to be at higher risk of malignancy. Symptomatic pre-menopausal women and asymptomatic post-menopausal women with polyps may be a group with intermediate-risk. These patients should undergo an individualized management plan, balancing both risks and benefits of surgical intervention after discussion with the patient.

KEYWORDS:

Clinical factors; Endometrial cancer; Endometrial polyps; Hysteroscopy; Oncologic risk

PMID:
25461364
DOI:
10.1016/j.ejogrb.2014.10.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center