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Infect Genet Evol. 2015 Jul;33:393-418. doi: 10.1016/j.meegid.2014.10.011. Epub 2014 Oct 30.

Molecular epidemiology and genomics of group A Streptococcus.

Author information

1
Department of Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA. Electronic address: debra_bessen@nymc.edu.
2
University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences, College of Pharmacy, Oklahoma City, OK 73117, USA. Electronic address: William-McShan@ouhsc.edu.
3
University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences, College of Pharmacy, Oklahoma City, OK 73117, USA. Electronic address: Scott-Van-Nguyen@ouhsc.edu.
4
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: AShetty@som.umaryland.edu.
5
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: SAgrawal@som.umaryland.edu.
6
Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: tettelin@som.umaryland.edu.

Abstract

Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a very high prevalence worldwide. This review highlights the genetic organization of the species and the important ecological considerations that impact its evolution. Recent advances are presented on the topics of molecular epidemiology, population biology, molecular basis for genetic change, genome structure and genetic flux, phylogenomics and closely related streptococcal species, and the long- and short-term evolution of GAS. The application of whole genome sequence data to addressing key biological questions is discussed.

KEYWORDS:

Epidemiology; Evolution; Genomics; Group A Streptococcus; Population biology; Streptococcus pyogenes

PMID:
25460818
PMCID:
PMC4416080
DOI:
10.1016/j.meegid.2014.10.011
[Indexed for MEDLINE]
Free PMC Article

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