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Curr Opin Cell Biol. 2015 Feb;32:39-47. doi: 10.1016/j.ceb.2014.10.005. Epub 2014 Nov 15.

Cytoskeletal crosstalk: when three different personalities team up.

Author information

1
FOM Institute AMOLF, 1098XG Amsterdam, The Netherlands.
2
FOM Institute AMOLF, 1098XG Amsterdam, The Netherlands. Electronic address: g.koenderink@amolf.nl.

Abstract

Cell shape and mechanics are determined by the interplay of three distinct cytoskeletal networks, made of actin filaments, microtubules, and intermediate filaments. These three types of cytoskeletal polymers have rather different structural and physical properties, enabling specific cellular functions. However, there is growing evidence that the three cytoskeletal subsystems also exhibit strongly coupled functions necessary for polarization, cell migration, and mechano-responsiveness. Here we summarize this evidence from a biophysical point of view, focusing on physical (direct) interactions between the cytoskeletal elements and their influence on cell mechanics and cell migration.

PMID:
25460780
DOI:
10.1016/j.ceb.2014.10.005
[Indexed for MEDLINE]

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