Format

Send to

Choose Destination
Curr Opin Pharmacol. 2014 Dec;19:153-8.

Transgenerational effects of obesogens and the obesity epidemic.

Author information

1
Department of Developmental and Cell Biology, 2011 Biological Sciences 3, Irvine, CA 92697-2300, USA.

Abstract

In the last three decades there has been a dramatic, worldwide increase in the incidence of obesity, particularly in Western societies. This trend has required a significant economic investment to treat obesity-related disorders such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. There is an urgent need to understand the factors that contribute to this increase in obesity in order to find new tools that will improve quality of life in affected individuals and to avoid the propagation of obesity to future generations. Endocrine disrupting chemicals have become an important piece of the obesity epidemic puzzle but little is known about the mechanism underlying their effects. In this commentary, we highlight recent work showing that the consequences of ancestral exposure to obesogenic chemicals results in the transmission of obesity-related phenotypes through at least three generations.

PMID:
25460228
PMCID:
PMC4297575
DOI:
10.1016/j.coph.2014.10.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center