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Mol Cell. 2014 Nov 20;56(4):469-80. doi: 10.1016/j.molcel.2014.11.001. Epub 2014 Nov 20.

The two faces of receptor interacting protein kinase-1.

Author information

1
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
2
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address: douglas.green@stjude.org.

Abstract

Receptor Interacting Protein Kinase-1 (RIPK1), a key player in inflammation and cell death, assumes opposite functions depending on the cellular context and its posttranslational modifications. Genetic evidence supported by biochemical and cellular biology approaches sheds light on the circumstances in which RIPK1 promotes or inhibits these processes.

PMID:
25459879
PMCID:
PMC4254517
DOI:
10.1016/j.molcel.2014.11.001
[Indexed for MEDLINE]
Free PMC Article

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