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Clin Perinatol. 2014 Dec;41(4):815-31. doi: 10.1016/j.clp.2014.08.006. Epub 2014 Sep 23.

Fetal programming, epigenetics, and adult onset disease.

Author information

1
Department of Pediatrics, Children's Hospital of Wisconsin, Medical College of Wisconsin, Suite 720, PO Box 1997, Milwaukee, WI 53201-1997, USA. Electronic address: rlane@mcw.edu.

Abstract

How early life events program adult disease is undergoing a transition from the broad field of maternal malnutrition to the current relevant issues of food deserts and prematurity. Although many adult diseases and morbidities associate with various early life events and programming, the morbidities of insulin resistance, cardiovascular disease, and obesity seem to be common end points of many early life events despite potential confounders.

KEYWORDS:

DNA methylation; Developmental origins of disease; Epigenetics; Food desert; Histone covalent modifications; Insulin growth factor 1; Insulin resistance; Obesity

PMID:
25459776
DOI:
10.1016/j.clp.2014.08.006
[Indexed for MEDLINE]

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