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Immunol Allergy Clin North Am. 2015 Feb;35(1):1-17. doi: 10.1016/j.iac.2014.09.002. Epub 2014 Oct 18.

The role of the early-life environment in the development of allergic disease.

Author information

1
Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA. Electronic address: gwegien1@hfhs.org.
2
Division of Allergy and Immunology, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA.
3
Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA.

Abstract

A consensus has been reached that the development of allergic disorders is strongly influenced by early life exposures. An overview of several prenatal and early life factors that have been investigated for their associations with development of childhood allergy is presented. Delivery mode, the gut microbiome, vitamin D, folate, breastfeeding, pets, antibiotics, environmental tobacco smoke, and airborne traffic pollutants are discussed. Although many studies suggest an effect, overall, no risk factors clearly increase or reduce the risk of allergic outcomes.

KEYWORDS:

Allergy; Asthma; Atopic dermatitis; Eczema; IgE; Prenatal

PMID:
25459574
PMCID:
PMC4427897
DOI:
10.1016/j.iac.2014.09.002
[Indexed for MEDLINE]
Free PMC Article

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