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Auris Nasus Larynx. 2015 Apr;42(2):170-2. doi: 10.1016/j.anl.2014.10.003. Epub 2014 Nov 4.

Sphenoid esthesioneuroblastoma arising from the hindmost olfactory filament.

Author information

1
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
2
Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: tnakagawa@ent.kuhp.kyoto-u.ac.jp.

Abstract

Esthesioneuroblastoma (ENB), or olfactory neuroblastoma, is a rare malignant neoplasm arising from the olfactory neuroepithelium. Typically, ENBs are found in the olfactory cleft with extension to the ethmoid sinuses or anterior skull base. Here we report a case of ENB located in the sphenoid sinus, which had been considered as an ectopic ENB. However, endoscopic resection revealed the continuity of the tumor with the hindmost olfactory filament. The present case suggests that an ENB in the sphenoid sinus was not ectopic, but arose from the normal olfactory neuroepithelium. This continuity of the ENB with this filament indicated that the tumor was not ectopic, and that there was possible tumor invasion into the olfactory neuroepithelium in the cribriform niche. Therefore, pathological examination of the olfactory neuroepithelium in the cribriform niche may be necessary in case of sphenoid ENBs.

KEYWORDS:

Ectopic tumor; Endoscopic surgery; Olfactory neuroblastomas; Sphenoid sinus

PMID:
25459497
DOI:
10.1016/j.anl.2014.10.003
[Indexed for MEDLINE]

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