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J Virol. 1989 Aug;63(8):3541-4.

Sendai virus infection of mice with protein malnutrition.

Author information

1
Division of Infectious Diseases, Children's Hospital, Boston, Massachusetts 02115.

Abstract

Sendai virus pneumonia was produced in BALB/c mice fed protein-deficient diets in an effort to understand the severity of viral pneumonia in infants in developing countries. Animals on the deficient diet became clinically malnourished, and some aspects of cellular immunity were altered. In protein-deprived animals, the 50% lethal dose of intranasally administered Sendai virus was over 1,000-fold lower, pulmonary virus titers were higher, the infection was prolonged, and lung infection was established at a lower inoculum than in normal animals.

PMID:
2545924
PMCID:
PMC250935
[Indexed for MEDLINE]
Free PMC Article

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