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Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Dec;118(6):674-83. doi: 10.1016/j.oooo.2014.09.005. Epub 2014 Sep 16.

Chemoprevention of oral cancer by topical application of black raspberries on high at-risk mucosa.

Author information

1
University College of Public Health, The Ohio State University, Columbus, OH, USA; College of Dentistry The Ohio State University, Columbus, OH, USA; School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: warnerbm@upmc.edu.
2
University College of Public Health, The Ohio State University, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
3
College of Dentistry The Ohio State University, Columbus, OH, USA.

Abstract

OBJECTIVE:

To evaluate the preclinical efficacy of topical administration of freeze-dried black raspberries (BRBs) to inhibit the progression of premalignant oral lesions and modulate biomarkers of cancer development in high at-risk mucosa (HARM).

STUDY DESIGN:

Hamster cheek pouches (HCPs) were treated with carcinogen for 6 weeks to initiate a HARM microenvironment. Subsequently, right HCPs were topically administered a BRB suspension in short-term or long-term studies. After 12 weeks, squamous cell carcinoma (SCC) multiplicity, SCC incidence, and cell proliferation rates were evaluated. mRNA expression was measured in short-term treated pouches for selected oral cancer biomarkers.

RESULTS:

SCC multiplicity (-41.3%), tumor incidence (-37.1%), and proliferation rate (-6.9%) were reduced in HCPs receiving BRBs. Topical BRBs correlated with an increase in RB1 expression in developing oral lesions.

CONCLUSIONS:

Topical BRBs inhibit SCC development when targeted to HARM tissues. These results support the translational role of BRBs to prevent oral cancer development in humans.

PMID:
25457886
PMCID:
PMC4254525
DOI:
10.1016/j.oooo.2014.09.005
[Indexed for MEDLINE]
Free PMC Article

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