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Alcohol. 2015 Jun;49(4):321-339. doi: 10.1016/j.alcohol.2014.07.016. Epub 2014 Oct 18.

Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches.

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Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
Department of Biological Sciences, Kent State University, Kent, OH 44242, USA.
Contributed equally


Research over the past decade has demonstrated substantial interactions between the circadian system and the processes through which alcohol affects behavior and physiology. Here we summarize the results of our collaborative efforts focused on this intersection. Using a combination of in vivo and in vitro approaches, we have shown that ethanol affects many aspects of the mammalian circadian system, both acutely as well as after chronic administration. Conversely, we have shown circadian influences on ethanol consumption. Importantly, we are beginning to delve into the cellular mechanisms associated with these effects. We are also starting to form a picture of the neuroanatomical bases for many of these actions. Finally, we put our current findings into perspective by suggesting new avenues of inquiry for our future efforts.


Circadian rhythms; Ethanol; GABA; Glutamate; Serotonin; Suprachiasmatic nucleus

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