Abstract
The photoredox-mediated coupling of benzylic ethers with Schiff bases has been accomplished. Direct benzylic C-H activation by a combination of a thiol catalyst with an iridium photocatalyst and subsequent radical-radical coupling with secondary aldimines affords a variety of β-amino ether products in good to excellent yields. Mechanistic studies suggest that a reductive quenching pathway of the photocatalyst is operable.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzyl Compounds / chemistry*
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Catalysis
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Ethers / chemical synthesis
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Ethers / chemistry*
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Imines / chemistry*
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Iridium / chemistry*
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Molecular Structure
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Organometallic Compounds / chemistry
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Oxidation-Reduction
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Photochemical Processes
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Schiff Bases / chemistry*
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Sulfhydryl Compounds / chemistry*
Substances
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Benzyl Compounds
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Ethers
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Imines
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Organometallic Compounds
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Schiff Bases
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Sulfhydryl Compounds
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Iridium