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Chem Biol. 2014 Nov 20;21(11):1457-62. doi: 10.1016/j.chembiol.2014.09.015.

N-terminal ArgD peptides from the classical Staphylococcus aureus Agr system have cytotoxic and proinflammatory activities.

Abstract

AgrD is the precursor for the autoinducing peptide in a quorum-sensing system regulating virulence phenotypes of the preeminent pathogen Staphylococcus aureus. Mass spectrometry-based methods, including molecular networking, identified formylated and nonformylated peptide variants derived from the AgrD N-terminal leader domain in S. aureus cell-free culture supernatants. Functional assessment of these peptides revealed unexpected bioactivities, including human cell-line cytotoxicity, modulation of neutrophil chemotaxis, neutrophil extracellular trap formation, and the aggravation of skin lesions in vivo.

PMID:
25457179
PMCID:
PMC4304878
DOI:
10.1016/j.chembiol.2014.09.015
[Indexed for MEDLINE]
Free PMC Article

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