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Int J Cardiol. 2014 Dec 20;177(3):912-7. doi: 10.1016/j.ijcard.2014.10.010. Epub 2014 Oct 20.

Galectin-3 predicts short- and long-term outcome in patients undergoing transcatheter aortic valve implantation (TAVI).

Author information

1
Medizinische Klinik für Kardiologie und Angiologie, Charité Campus Mitte - Universitätsmedizin Berlin, Germany.
2
Labor Berlin - Charité Vivantes Services GmbH, Berlin, Germany.
3
Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Charité Campus Mitte - Universitätsmedizin Berlin, Germany.
4
Klinik für Kardiovaskuläre Chirurgie, Charité Campus Mitte - Universitätsmedizin Berlin, Germany.
5
Medizinische Klinik für Kardiologie und Angiologie, Charité Campus Mitte - Universitätsmedizin Berlin, Germany. Electronic address: karl.stangl@charite.de.

Abstract

Until now, no reliable biomarker has become available for short- or long-term outcome prediction in patients undergoing transcatheter aortic valve implantation (TAVI). Our goal was to investigate whether galectin-3 is also suited for risk assessment in TAVI patients. Galectin-3, a novel marker indicative for myocardial fibrosis, has prognostic value in heart failure. We included 101 patients undergoing TAVI in this prospective, single-center, observational study. Baseline galectin-3 levels were correlated to the VARC 30-day safety and one-year efficacy endpoint as well as to total mortality and cardiovascular events at one year. At baseline, mean galectin-3 level for the entire group was 18.1 (± 11.1) ng/ml. Of the 101 patients, 36 had a galectin-3 value above the cut off value of 17.8 ng/ml. These patients had significantly higher systolic pulmonary artery and capillary wedge pressures. The hazard ratio in patients with galectin-3 > 17.8 ng/ml was 3.36 (95% confidence interval, CI: 1.47-7.69; p=0.004) for the VARC 30-day safety endpoint, 5.12 (95% CI: 2.10-12.47; p<0.001) for one-year cardiovascular events, and 4.48 (95% CI: 1.56-12.91; p=0.005) for all-cause mortality. This prediction remained stable even after adjusting for possible confounders including age, sex, glomerular filtration rate, and NT-proBNP. Furthermore, the prediction was even more valuable when combining galectin-3 with NTproBNP. In summary elevated galectin-3 levels are associated with adverse outcome after TAVI. Combining galectin-3 with NT-proBNP provides additive predictive value of risk stratification.

KEYWORDS:

Aortic valve stenosis; Galectin-3; Transcatheter aortic valve implantation

PMID:
25456698
DOI:
10.1016/j.ijcard.2014.10.010
[Indexed for MEDLINE]

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