Format

Send to

Choose Destination
Am J Otolaryngol. 2015 Mar-Apr;36(2):146-52. doi: 10.1016/j.amjoto.2014.10.006. Epub 2014 Oct 8.

Erythrocyte membrane antigen frequencies in patients with Type II congenital smell loss.

Author information

1
Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, #20, Washington, DC, United States. Electronic address: wstateman@gmail.com.
2
Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, #20, Washington, DC, United States. Electronic address: doc@tasteandsmell.com.
3
Center for Molecular Nutrition and Sensory Disorders, The Taste and Smell Clinic, 5125 MacArthur Blvd, NW, #20, Washington, DC, United States. Electronic address: abknoppel@gmail.com.
4
Department of Transfusion Medicine, NIH Clinical Center, 10 Center Drive-MSC 1184, Building 10, Room 1C711, Bethesda, MD, United States. Electronic address: flegelwa@cc.nih.gov.

Abstract

OBJECTIVE:

The objective of this study was to determine whether there are genetic factors associated with Type II congenital smell loss.

STUDY DESIGN:

The expression frequencies of 16 erythrocyte antigens among patients with Type II congenital smell loss were determined and compared to those of a large control group.

METHODS:

Blood samples were obtained from 99 patients with Type II congenital smell loss. Presence of the erythrocyte surface antigens A, B, M, N, S, s, Fy(a), Fy(b), D, C, c, E, e, K, Jk(a), and Jk(b) was analyzed by blood group serology. Comparisons of expression frequencies of these antigens were made between the patients and a large control group.

RESULTS:

Patients tested for the Duffy b antigen (Fy(b) haplotype) exhibited a statistically significant 11% decrease in expression frequency compared to the controls. There were no significant differences between patients and controls in the expression frequencies for all other erythrocyte antigens (A, B, M, N, S, s, Fy(a), D, C, c, E, e, K, Jk(a), or Jk(b)).

CONCLUSIONS:

These findings describe the presence of a previously unrevealed genetic tendency among patients with Type II congenital smell loss related to erythrocyte surface antigen expression. The deviation in expression rate of Duffy b suggests a target gene and chromosome region in which future research into this form of congenital smell loss may reveal a more specific genetic basis for Type II congenital smell loss.

PMID:
25456515
PMCID:
PMC4330100
DOI:
10.1016/j.amjoto.2014.10.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center